己烯雌酚代謝房室模型建模與控制.doc
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己烯雌酚代謝房室模型建模與控制,1.18萬字自己原創(chuàng)的畢業(yè)論文，僅在本站獨(dú)家出售，重復(fù)率低，推薦下載使用摘要 己烯雌酚（stilbestrol）是人工合成的非甾體雌激素物質(zhì)，能產(chǎn)生與天然雌二醇相同的所有藥理與治療作用。主要用于雌激素低下癥及激素平衡失調(diào)引起的功能性出血、閉經(jīng)。但是孕婦服用此藥，其女性后代在青春期后宮頸和陰...
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此文檔由會員 淘寶大夢 發(fā)布
己烯雌酚代謝房室模型建模與控制
1.18萬字
自己原創(chuàng)的畢業(yè)論文，僅在本站獨(dú)家出售，重復(fù)率低，推薦下載使用
摘要 己烯雌酚（Stilbestrol）是人工合成的非甾體雌激素物質(zhì)，能產(chǎn)生與天然雌二醇相同的所有藥理與治療作用。主要用于雌激素低下癥及激素平衡失調(diào)引起的功能性出血、閉經(jīng)。但是孕婦服用此藥，其女性后代在青春期后宮頸和陰道的腺病及腺癌發(fā)生率升高，男性后代生殖道異常和精子異常發(fā)生率也增加。為了在保證己烯雌酚治療效果的前提下減小己烯雌酚在治療過程中產(chǎn)生的副作用，我們需要研究如何控制己烯雌酚在人體內(nèi)的代謝殘留。
變結(jié)構(gòu)控制方法具有對系統(tǒng)內(nèi)外部干擾的完全自適應(yīng)性及易于實(shí)現(xiàn)的特點(diǎn)，因而稱為處理控制系統(tǒng)的有利工具?；Ｗ兘Y(jié)構(gòu)控制法更是在變結(jié)構(gòu)控制方法的基礎(chǔ)上增強(qiáng)其魯棒性，對時變系統(tǒng)、不確定系統(tǒng)等同樣具有良好的控制作用。本文基于己烯雌酚在人體各器官轉(zhuǎn)移模型，結(jié)合生物建模中的多房室模型，通過線性系統(tǒng)極點(diǎn)配置設(shè)計(jì)變結(jié)構(gòu)控制器，使非穩(wěn)定的系統(tǒng)達(dá)到某種意義下的穩(wěn)定狀態(tài)或使已穩(wěn)定的系統(tǒng)盡快達(dá)到穩(wěn)定狀態(tài)，以縮短己烯雌酚停留在人體內(nèi)的時間，減少其對人體的危害。
本文通過建立己烯雌酚在人體中代謝的房室模型，構(gòu)建相應(yīng)的控制系統(tǒng)方程，，基于Lyapunov函數(shù)法研究了己烯雌酚在人體內(nèi)各器官轉(zhuǎn)移模型的變結(jié)構(gòu)控制問題，得到了使系統(tǒng)盡快達(dá)到穩(wěn)定平衡點(diǎn)的變結(jié)構(gòu)控制器，最后利用matlab進(jìn)行仿真模擬，檢驗(yàn)控制結(jié)果。
關(guān)鍵詞：己烯雌酚 藥物代謝 房室模型建模 滑模變結(jié)構(gòu)控制 仿真與建模
Modeling and Control for Compartment Model of Stilbestrol Metabolism
Abestract Diethylstilbestrol is a synthetic non-steroidal estrogens , estradiol can produce all of the same natural pharmacology and therapeutic effects . Mainly for low estrogen hormone imbalance caused by disease and functional bleeding, amenorrhea . But pregnant women taking the drug , their female offspring after puberty increased incidence of adenosis and adenocarcinoma of the cervix and vagina , male offspring reproductive tract abnormalities and increased incidence of abnormal sperm . To reduce side effects of diethylstilbestrol in the treatment process to produce the therapeutic effect of ensuring diethylstilbestrol premise, we need to consider how to control the metabolism of the human body diethylstilbestrol residues.
Variable Structure Control with external interference within the system is completely self-adaptive and easy to implement , and therefore a useful tool called process control system.Sliding Mode Variable Structure Control Act is to enhance its robustness based on variable structure control methods, time-varying systems, uncertain systems, also has good control effect.Based diethylstilbestrol in human organs metastasis model , combining biological modeling multi- compartment model , designed by pole placement linear systems variable structure controller so that the non- stable system reaches a steady state , or make some sense already stable system reaches a steady state as soon as possible in order to stay in the human body diethylstilbestrol shorten time to reduce the harm to the human body.
Through the establishment of compartmental models diethylstilbestrol metabolism in the human body , build the appropriate control system equations to study the changing structure of the human body diethylstilbestrol each organ metastasis model law pole placement control problems , got the system as soon as possible reach a stable equilibrium point variable structure controller , finally using Matlab simulation , test control results.
Keywords Stilestrbol Drug metabolism Compartmental modeling Sliding mode variable structure control Modeling and simulation
目 錄
摘要 I
Abestract II
第一章 緒論 1
1.1己烯雌酚代謝的建模與控制研究背景 1
1.2己烯雌酚代謝的建模的研究現(xiàn)狀 2
1.3本文主要研究內(nèi)容 3
第二章 己烯雌酚代謝房室模型 5
2.1房室模型 5
2.1.1房室的基本概念 5
2.1.2房室系統(tǒng)的建模 6
2.1.3房室模型的仿真 8
2.2己烯雌酚代謝房室模型的建模 10
第三章 己烯雌酚代謝的控制 12
3.1 變結(jié)構(gòu)控制 12
3.1.1變結(jié)構(gòu)控制系統(tǒng)的基本概念 12
3.1.2變結(jié)構(gòu)控制的發(fā)展概況 12
3.1.3變結(jié)構(gòu)控制系統(tǒng)的數(shù)學(xué)描述 13
3.2己烯雌酚代謝模型的滑模變結(jié)構(gòu)控制 15
3.3 仿真結(jié)果 17
總結(jié)與展望 19
致 謝 20
參考文獻(xiàn) 21
附錄 22
1.18萬字
自己原創(chuàng)的畢業(yè)論文，僅在本站獨(dú)家出售，重復(fù)率低，推薦下載使用
摘要 己烯雌酚（Stilbestrol）是人工合成的非甾體雌激素物質(zhì)，能產(chǎn)生與天然雌二醇相同的所有藥理與治療作用。主要用于雌激素低下癥及激素平衡失調(diào)引起的功能性出血、閉經(jīng)。但是孕婦服用此藥，其女性后代在青春期后宮頸和陰道的腺病及腺癌發(fā)生率升高，男性后代生殖道異常和精子異常發(fā)生率也增加。為了在保證己烯雌酚治療效果的前提下減小己烯雌酚在治療過程中產(chǎn)生的副作用，我們需要研究如何控制己烯雌酚在人體內(nèi)的代謝殘留。
變結(jié)構(gòu)控制方法具有對系統(tǒng)內(nèi)外部干擾的完全自適應(yīng)性及易于實(shí)現(xiàn)的特點(diǎn)，因而稱為處理控制系統(tǒng)的有利工具?；Ｗ兘Y(jié)構(gòu)控制法更是在變結(jié)構(gòu)控制方法的基礎(chǔ)上增強(qiáng)其魯棒性，對時變系統(tǒng)、不確定系統(tǒng)等同樣具有良好的控制作用。本文基于己烯雌酚在人體各器官轉(zhuǎn)移模型，結(jié)合生物建模中的多房室模型，通過線性系統(tǒng)極點(diǎn)配置設(shè)計(jì)變結(jié)構(gòu)控制器，使非穩(wěn)定的系統(tǒng)達(dá)到某種意義下的穩(wěn)定狀態(tài)或使已穩(wěn)定的系統(tǒng)盡快達(dá)到穩(wěn)定狀態(tài)，以縮短己烯雌酚停留在人體內(nèi)的時間，減少其對人體的危害。
本文通過建立己烯雌酚在人體中代謝的房室模型，構(gòu)建相應(yīng)的控制系統(tǒng)方程，，基于Lyapunov函數(shù)法研究了己烯雌酚在人體內(nèi)各器官轉(zhuǎn)移模型的變結(jié)構(gòu)控制問題，得到了使系統(tǒng)盡快達(dá)到穩(wěn)定平衡點(diǎn)的變結(jié)構(gòu)控制器，最后利用matlab進(jìn)行仿真模擬，檢驗(yàn)控制結(jié)果。
關(guān)鍵詞：己烯雌酚 藥物代謝 房室模型建模 滑模變結(jié)構(gòu)控制 仿真與建模
Modeling and Control for Compartment Model of Stilbestrol Metabolism
Abestract Diethylstilbestrol is a synthetic non-steroidal estrogens , estradiol can produce all of the same natural pharmacology and therapeutic effects . Mainly for low estrogen hormone imbalance caused by disease and functional bleeding, amenorrhea . But pregnant women taking the drug , their female offspring after puberty increased incidence of adenosis and adenocarcinoma of the cervix and vagina , male offspring reproductive tract abnormalities and increased incidence of abnormal sperm . To reduce side effects of diethylstilbestrol in the treatment process to produce the therapeutic effect of ensuring diethylstilbestrol premise, we need to consider how to control the metabolism of the human body diethylstilbestrol residues.
Variable Structure Control with external interference within the system is completely self-adaptive and easy to implement , and therefore a useful tool called process control system.Sliding Mode Variable Structure Control Act is to enhance its robustness based on variable structure control methods, time-varying systems, uncertain systems, also has good control effect.Based diethylstilbestrol in human organs metastasis model , combining biological modeling multi- compartment model , designed by pole placement linear systems variable structure controller so that the non- stable system reaches a steady state , or make some sense already stable system reaches a steady state as soon as possible in order to stay in the human body diethylstilbestrol shorten time to reduce the harm to the human body.
Through the establishment of compartmental models diethylstilbestrol metabolism in the human body , build the appropriate control system equations to study the changing structure of the human body diethylstilbestrol each organ metastasis model law pole placement control problems , got the system as soon as possible reach a stable equilibrium point variable structure controller , finally using Matlab simulation , test control results.
Keywords Stilestrbol Drug metabolism Compartmental modeling Sliding mode variable structure control Modeling and simulation
目 錄
摘要 I
Abestract II
第一章 緒論 1
1.1己烯雌酚代謝的建模與控制研究背景 1
1.2己烯雌酚代謝的建模的研究現(xiàn)狀 2
1.3本文主要研究內(nèi)容 3
第二章 己烯雌酚代謝房室模型 5
2.1房室模型 5
2.1.1房室的基本概念 5
2.1.2房室系統(tǒng)的建模 6
2.1.3房室模型的仿真 8
2.2己烯雌酚代謝房室模型的建模 10
第三章 己烯雌酚代謝的控制 12
3.1 變結(jié)構(gòu)控制 12
3.1.1變結(jié)構(gòu)控制系統(tǒng)的基本概念 12
3.1.2變結(jié)構(gòu)控制的發(fā)展概況 12
3.1.3變結(jié)構(gòu)控制系統(tǒng)的數(shù)學(xué)描述 13
3.2己烯雌酚代謝模型的滑模變結(jié)構(gòu)控制 15
3.3 仿真結(jié)果 17
總結(jié)與展望 19
致 謝 20
參考文獻(xiàn) 21
附錄 22
